| Gerke J, Lorenz K, Cohen B Genetic interactions between transcription factors cause natural variation in yeast 2009 Jan, Science, 323(5913):498-501 | Saccharomyces cerevisiae | |
| Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast. 2008 Sep, Science, [Epub ahead of print]Click here to read | discovery » techniques » pombe epistasis mapper (PEM) | Schizosaccharomyces pombe |
| Dickinson WJ Synergistic Fitness Interactions and a High Frequency of Beneficial Changes Among Mutations Accumulated Under Relaxed Selection in Saccharomyces cerevisiae. 2008 Feb, Genetics, [Epub ahead of print] | applications » population genetics & evolution | Saccharomyces cerevisiae |
| Casci T. Genetic screens: Epistasis on the double. 2007 Nov, Nat. Rev. Genet., 8:826-827 | discovery » techniques » pombe epistasis mapper (PEM) | Schizosaccharomyces pombe |
| Nielsen O. Fission yeast goes synthetic. 2007 Oct, Nat. Methods, 4(10):777-778 | discovery » techniques » pombe epistasis mapper (PEM) | Schizosaccharomyces pombe |
| Roguev A., Wiren M., Weissman J. S., Krogan N. J. High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. 2007 Oct, Nat. Methods, 4(10):861-866 | discovery » techniques » pombe epistasis mapper (PEM) | Schizosaccharomyces pombe |
| Boone C., Bussey H., Andrews B. J. Exploring genetic interactions and networks in yeast. 2007 Jun, Nat. Rev. Genet., 8(6):437:449 | Saccharomyces cerevisiae | |
| Dettman J. R., Sirjusingh C., Kohn L. M., Anderson J. B. Incipient speciation by divergent adaptation and antagonistic epistasis in yeast. 2007 May, Nature, 447(7144):585-588 | applications » population genetics & evolution » speciation | Saccharomyces cerevisiae |
| Lehner B. Modelling genotype-phenotype relationships and human disease with genetic interaction networks. 2007 May, J. Exp. Biol., 210(Pt 9):1559-1566 | applications » disease association studies discovery » techniques | Saccharomyces cerevisiae, Homo sapiens, Caenorhabditis elegans |
| Ulitsky I., Shamir R. Pathway redundancy and protein essentiality revealed in the Saccharomyces cerevisiae interaction networks. 2007 Apr, Mol. Syst. Biol., 3:104 | interpretation & analysis applications » prediction of gene function | Saccharomyces cerevisiae |
| Collins S. R., Miller K. M., Maas N. L., Roguev A., Fillingham J., Chu C. S., Schuldiner M., Gebbia M., Recht J., Shales M., Ding H., Xu H., Han J., Ingvarsdottir K., Cheng B., Andrews B., Boone C., Berger S. L., Hieter P., Zhang Z., Brown G. W., Ingles C. J., Emili A., Allis C. D., Toczyski D. P., Weissman J. S., Greenblatt J. F., Krogan N. J. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. 2007 Apr, Nature, 446(7137):806-810 | discovery » techniques » SGA » E-MAP | Saccharomyces cerevisiae |
| Memarian N., Jessulat M., Alirezaie J., Mir-Rashed N., Xu J., Zareie M., Smith M., Golshani A. Colony size measurement of the yeast gene deletion strains for functional genomics. 2007 Apr, BMC Bioinformatics, 8:117 | discovery » techniques » SGA » computational colony size measurement | Saccharomyces cerevisiae |
| Jasnos L., Korona R. Epistatic buffering of fitness loss in yeast double deletion strains. 2007 Apr, Nat. Genet., 39(4):550-554 | applications » population genetics & evolution | Saccharomyces cerevisiae |
| Zeyl C. How missing genes interact. 2007 Apr, Nat. Genet., 39:440-442 | Saccharomyces cerevisiae | |
| Carter G. W., Prinz S., Neou C., Shelby J. P., Marzolf B., Thorsson V., Galitski T. Prediction of phenotype and gene expression for combinations of mutations. 2007 Mar, Mol. Syst. Biol., 3:96 | discovery » techniques » QTL + gene expression | Saccharomyces cerevisiae |
| Onge R. P., Mani R., Oh J., Proctor M., Fung E., Davis R. W., Nislow C., Roth F. P., Giaever G. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. 2007 Feb, Nat. Genet., 39(2):199-206 | discovery interpretation & analysis | Saccharomyces cerevisiae |
| Pan X., Yuan D. S., Ooi S. L., Wang X., Sookhai-Mahadeo S., Meluh P., Boeke J. D. dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae. 2007 Feb, Methods, 41(2):206-221 | discovery » techniques » dSLAM | Saccharomyces cerevisiae |
| Haarer B., Viggiano S., Hibbs M. A., Troyanskaya O. G., Amberg D. C.
Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies. 2007 Jan, Genes Dev., 21(2):148-159 | discovery » techniques » genomic haploinsufficiency modifier screen concepts » haploinsufficiency | Saccharomyces cerevisiae |
| Shah N. A., Laws R. J., Wardman B., Zhao L. P., Hartman J. L. IV Accurate, precise modeling of cell proliferation kinetics from time-lapse imaging and automated image analysis of agar yeast culture arrays. 2007 Jan, BMC Syst. Biol, 1:3 | discovery » techniques » SGA » computational colony size measurement | Saccharomyces cerevisiae |
| Schuldiner M., Collins S. R., Weissman J. S., Krogan N. J. Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. 2006 Dec, Methods, 40(4):344-252 | discovery » techniques » SGA » E-MAP | Saccharomyces cerevisiae |
| Sanjuan R., Elena S.F. Epistasis correlates to genomic complexity. 2006 Sep, Proc. Natl. Acad. Sci. U.S.A., 103(39):14402-14405 | applications » population genetics & evolution | Aspergillus niger, Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Vesicular stomatitis virus (VSV) |
| Deutscher D., Meilijson I., Kupiec M., Ruppin E. Multiple knockout analysis of genetic robustness in the yeast metabolic network. 2006 Sep, Nat. Genet., 38(9):993-998 | Saccharomyces cerevisiae | |
| Pan X., Ye P., Yuan D.S., Wang X., Bader J.S., Boeke J.D. A DNA integrity network in the yeast Saccharomyces cerevisiae. 2006 Mar, Cell, 124(5):1069-1081 | discovery » techniques » dSLAM | Saccharomyces cerevisiae |
| Baetz K., Measday V., Andrews B. Revealing hidden relationships among yeast genes involved in chromosome segregation using systematic synthetic lethal and synthetic dosage lethal screens. 2006 Mar, Cell Cycle, 5(6):592-595 | discovery » techniques » SGA discovery » techniques » SDL | Saccharomyces cerevisiae |
| Sopko R., Huang D., Preston N., Chua G., Papp B., Kafadar K., Snyder M., Oliver S. G., Cyert M., Hughes T. R., Boone C., Andrews B. Mapping pathways and phenotypes by systematic gene overexpression. 2006 Feb, Mol. Cell, 21:319-330 | discovery » techniques » SDL | Saccharomyces cerevisiae |
| Barbour L., Xiao W. Synthetic lethal screen. 2006 Jan, Methods Mol. Biol., 313:161-169 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Collins S.R., Schuldiner M., Krogan N.J., Weissman J.S. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. 2006 Jan, Genome Biol., 7:R63 | interpretation & analysis discovery » techniques » SGA » E-MAP | Saccharomyces cerevisiae |
| Ooi S.L., Pan X., Peyser B.D., Ye P., Meluh P.B., Yuan D.S., Irizarry R.A., Bader J.S., Spencer F.A., Boeke J.D. Global synthetic-lethality analysis and yeast functional profiling. 2006 Jan, Trends Genet., 22(1):56-63 | concepts » synthetic lethality | Saccharomyces cerevisiae |
| Tong A. H., Boone C. Synthetic genetic array analysis in Saccharomyces cerevisiae. 2006 Jan, Methods Mol. Biol., 313 | discovery » techniques » SGA | Saccharomyces cerevisiae |
| Conibear E. An E-MAP of the ER. 2005 Nov, Cell, 123(3):366-368 | discovery » techniques » SGA » E-MAP | Saccharomyces cerevisiae |
| Wong S. L., Zhang L. V., Roth F. P. Discovering functional relationships: biochemistry versus genetics. 2005 Aug, Trends Genet., 21(8):424-427 | interpretation & analysis | Saccharomyces cerevisiae |
| Zhang L. V., King O. D., Wong S. L., Goldberg D. S., Tong A. H., Lesage G., Andrews B., Bussey H., Boone C., Roth F. P. Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. 2005 Jun, J. Biol., 4(2):6 | interpretation & analysis | Saccharomyces cerevisiae |
| Davierwala A. P., Haynes J., Li Z., Brost R. L., Robinson M. D., Yu L., Mnaimneh S., Ding H., Zhu H., Chen Y., Cheng X., Brown G. W., Boone C., Andrews B. J., Hughes T. R. The synthetic genetic interaction spectrum of essential genes. 2005 Jan, Nat. Genet., 37(10):1147-1152 | discovery » techniques » SGA | Saccharomyces cerevisiae |
| Measday V., Baetz K., Guzzo J., Yuen K., Kwok T., Sheikh B., Ding H., Ueta R., Hoac T., Cheng B., Pot I., Tong A., Yamaguchi-Iwai Y., Boone C., Hieter P., Andrews B.
Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. 2005 Jan, Proc. Natl. Acad. Sci. U.S.A., 102(39):13956-13961 | discovery » techniques » SGA discovery » techniques » SDL | Saccharomyces cerevisiae |
| Qi Y., Ye P., Bader J. S. Genetic interaction motif finding by expectation maximization - a novel statistical model for inferring gene modules from synthetic lethality. 2005 Jan, BMC Bioinformatics, 6:288 | interpretation & analysis » techniques » GIMF concepts » synthetic lethality | Saccharomyces cerevisiae |
| Schuldiner M., Collins S.R., Thompson N.J., Denic V., Bhamidipati A., Punna T., Ihmels J., Andrews B., Boone C., Greenblatt J.F., Weissman J.S., Krogan N.J. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. 2005 Jan, Cell, 123:507-519 | discovery » techniques » SGA » E-MAP | Saccharomyces cerevisiae |
| Segre D., Deluna A., Church G.M., Kishony R. Modular epistasis in yeast metabolism. 2005 Jan, Nat. Genet., 37(1):77-83 | discovery » techniques » computational prediction » flux balance analysis (FBA) | Saccharomyces cerevisiae |
| Yamada T., Kawashima S., Mamitsuka H., Goto S., Kanehisa M. Comprehensive analysis and prediction of synthetic lethality using subcellular locations. 2005 Jan, Genome Inform., 16(1):150-158 | interpretation & analysis concepts » synthetic lethality | Saccharomyces cerevisiae |
| Ye P., Peyser B. D., Pan X., Boeke J. D., Spencer F. A., Bader J. S.
Gene function prediction from congruent synthetic lethal interactions in yeast. 2005 Jan, Mol. Syst. Biol., 1:2005.0026 | concepts » synthetic lethality interpretation & analysis | Saccharomyces cerevisiae |
| Hartwell L. H. Yeast and cancer. 2004 Aug, Biosci. Rep., 24(4-5):523-544 | interpretation & analysis applications » disease association studies » cancer | Saccharomyces cerevisiae, Homo sapiens |
| Baetz K. K., Krogan N. J., Emili A., Greenblatt J., Hieter P. The ctf13-30/CTF13 Genomic Haploinsufficiency Modifier Screen Identifies the Yeast Chromatin Remodeling Complex RSC, Which Is Required for the Establishment of Sister Chromatid Cohesion. 2004 Jan, Mol. Cell. Biol., 24(3):1232-1244 | discovery » techniques » genomic haploinsufficiency modifier screen | Saccharomyces cerevisiae |
| Hartman J. L. IV, Tippery N. P. Systematic quantification of gene interactions by phenotypic array analysis. 2004 Jan, Genome Biol., 5(7):R49 | discovery | Saccharomyces cerevisiae |
| Kaufman A., Kupiec M., Ruppin E. Multi-knockout genetic network analysis: the Rad6 example. 2004 Jan, CSB, 332-340 | interpretation & analysis » techniques » MSA | Saccharomyces cerevisiae |
| Pan X, Yuan DS, Xiang D, Wang X, Sookhai-Mahadeo S, Bader JS, Hieter P, Spencer F, Boeke JD. A robust toolkit for functional profiling of the yeast genome. 2004 Jan, Mol. Cell, 16(3):487-496 | discovery » techniques » dSLAM | Saccharomyces cerevisiae |
| Tong A.H.Y., Lesage G., Bader G.D., Ding H., Xu H., Xin X., Young J., Berriz G.F., Brost R.L., Chang M., Chen Y.Q., Cheng X., Chua G., Friesen H., Goldberg D.S., Haynes J., Humphries C., He G., Hussein S., Ke L., Krogan N., Li Z., Levinson J.N., Lu H., Me´nard P., Munyana,C., Parsons A.B., Ryan O., Tonikian R., Roberts T., Sdicu A.-M., Shapiro J., Sheikh B., Suter B., Wong S.L., Zhang L.V., Zhu H., Burd C.G., Munro S., Sander C., Rine J., Greenblatt J., Peter M., Bretscher A., Bell G., Roth F.P., Brown G.W., Andrews B., Bussey H., Boone C. Global Mapping of the Yeast Genetic Interaction Network. 2004 Jan, Science, 303:808-813 | discovery » techniques » SGA | Saccharomyces cerevisiae |
| Tucker C. L., Fields S. Lethal combinations. 2003 Nov, Nat. Genet., 35(3):204-205 | Saccharomyces cerevisiae | |
| Bader G. D., Heilbut A., Andrews B., Tyers M., Hughes T., Boone C. Functional genomics and proteomics: charting a multidimensional map of the yeast cell. 2003 Jul, Trends Cell Biol., 13(7):344-356 | Saccharomyces cerevisiae | |
| Goehring A. S., Mitchell D. A., Tong A. H., Keniry M. E., Boone C., Sprague G. F. Jr. Synthetic lethal analysis implicates Ste20p, a p21-activated protein kinase, in polarisome activation. 2003 Apr, Mol. Biol. Cell, 14(4):1501-1516 | examples » synthetic lethality » enzyme-substrate relationship discovery » techniques » SGA | Saccharomyces cerevisiae |
| Koren A., Ben-Aroya S., Steinlauf R., Kupiec M. Pitfalls of the synthetic lethality screen in Saccharomyces cerevisiae: an improved design. 2003 Jan, Curr. Genet., 43(1):62-69 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Szafraniec K., Wloch D. M., Sliwa P., Borts R. H., Korona R. Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae. 2003 Jan, Genet. Res., 82(1):19-31 | discovery | Saccharomyces cerevisiae |
| Jorgensen P., Nelson B., Robinson M.D., Chen Y., Andrews B., Tyers M., Boone C. High-Resolution Genetic Mapping With Ordered Arrays of Saccharomyces cerevisiae Deletion Mutants. 2002 Jan, Genetics, 162:1091-1099 | discovery » techniques » SGA | Saccharomyces cerevisiae |
| Nigavekar S. S., Cannon J. F. Characterization of genes that are synthetically lethal with ade3 or leu2 in Saccharomyces cerevisiae. 2002 Jan, Yeast, 19(2):115-122 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Forsburg S. L. The art and design of genetic screens: yeast. 2001 Jan, Nat. Rev. Genet., 2(9):659-668 | discovery » techniques interpretation & analysis applications » prediction of gene function | Saccharomyces cerevisiae, Schizosaccharomyces pombe |
| Mullen J.R., Kaliraman V., Ibrahim S.S., Brill S.J. Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. 2001 Jan, Genetics, 157:103-118 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Tong A. H., Evangelista M., Parsons A. B., Xu H., Bader G. D., Page N., Robinson M., Raghibizadeh S., Hogue C. W., Bussey H., Andrews B., Tyers M., Boone C.
Systematic genetic analysis with ordered arrays of yeast deletion mutants. 2001 Jan, Science, 294(5550):2364-2368 | discovery » techniques » SGA | Saccharomyces cerevisiae |
| Finger F. P., Novick P. Synthetic interaction of the post-Golgi sec mutations of Saccharomyces cerevisiae. 2000 Nov, Genetics, 156(3):943-951 | examples » synthetic lethality » within pathway | Saccharomyces cerevisiae |
| Barbour L., Zhu Y., Xiao W. Improving synthetic lethal screens by regulating the yeast centromere sequence. 2000 Jan, Genome, 43(5):910-917 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Kroll E. S., Hyland K. M., Hieter P., Li J. J. Establishing genetic interactions by a synthetic dosage lethality phenotype. 1996 Jan, Genetics, 143(1):95-102 | discovery » techniques » SDL concepts | Saccharomyces cerevisiae |
| Cairns B.R., Ramer S.W., Kornberg R.D. Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. 1992 Jan, Genes Dev., 6:1305-1318 | examples » epistasis | Saccharomyces cerevisiae |
| Surana U., Robitsch H., Schuster T., Fitch I., Futcher A.B., Nasmyth K. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. 1991 Apr, Cell, 65(1):145-161 | examples » dosage suppression | Saccharomyces cerevisiae |
| Bender A., Pringle J.R. Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. 1991 Jan, Mol. Cell. Biol., 11:1295-1305 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Kaiser C. A., Schekman R. Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. 1990 May, Cell, 61(4):723-733 | examples » synthetic lethality » within pathway | Saccharomyces cerevisiae |
| Novick P., Osmond B.C., Botstein D. Suppressors of yeast actin mutations. 1989 Jan, Genetics, 121:659-674 | examples » synthetic lethality | Saccharomyces cerevisiae |
| Basson M. E., Moore R. L., O'Rear J., Rine J. Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes. 1987 Dec, Genetics, 117(4):645-655 | discovery » techniques » plasmid dependency assay | Saccharomyces cerevisiae |
| Sternberg P., Stern M. J., Clark I., Herskowitz I. Activation of the yeast HO gene by release from multiple negative controls. 1987 Feb, Cell, 48(4):567-577 | examples » epistasis | Saccharomyces cerevisiae |
| Hartwell L.H., Culotti J., Pringle J., Reid B. Genetic control of the cell division cycle in yeast: a model. 1974 Jan, Science, 183:46-51 | examples » epistasis | Saccharomyces cerevisiae |