Reviews on genetic interactions

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Gunsalus KC
A Caenorhabditis elegans genetic-interaction map wiggles into view.
2008 Mar, J. Biol., 7(3):8
Caenorhabditis elegans
Assimes TL, Olshen AB, Narasimhan B, Olshen RA
Associations among multiple markers and complex disease: models, algorithms, and applications.
2008 Mar, Adv. Genet., 60:437-464
applications » disease association studies
Maxwell C. A., Moreno V., Sole X., Gomez L., Hernandez P., Urruticoechea A., Pujana M. A.
Genetic interactions: the missing links for a better understanding of cancer susceptibility, progression and treatment.
2008 Jan, Mol. Cancer, 7(1):4
applications » disease association studies » cancer
Li W.
Three lectures on case-control genetic association analysis.
2007 Dec, Brief. Bioinformatics, 9(1):1-13
applications » disease association studies
Beyer A., Bandyopadhyay S., Ideker T.
Integrating physical and genetic maps: from genomes to interaction networks.
2007 Sep, Nat. Rev. Genet., 8(9):699-710
interpretation & analysis
Eyre-Walker A., Keightley P. D.
The distribution of fitness effects of new mutations.
2007 Aug, Nat. Rev. Genet., 8(8):610:618
Su X., Hayton K., Wellems T. E.
Genetic linkage and association analyses for trait mapping in Plasmodium falciparum.
2007 Jul, Nat. Rev. Genet., 8:497-506
applications » disease association studies » drug responsePlasmodium falciparum
Boone C., Bussey H., Andrews B. J.
Exploring genetic interactions and networks in yeast.
2007 Jun, Nat. Rev. Genet., 8(6):437:449
Saccharomyces cerevisiae
Lehner B.
Modelling genotype-phenotype relationships and human disease with genetic interaction networks.
2007 May, J. Exp. Biol., 210(Pt 9):1559-1566
applications » disease association studies

discovery » techniques

Saccharomyces cerevisiae, Homo sapiens, Caenorhabditis elegans
Bourgain C., Genin E., Cox N., Clerget-Darpoux F.
Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?
2007 Mar, Eur. J. Hum. Genet., 15:260-263
applications » disease association studies
Presgraves D. C.
Speciation genetics: epistasis, conflict and the Origin of Species
2007 Feb, Curr. Biol., 17(4):R125-R127
applications » population genetics & evolution » speciation » Dobzhansky-Muller model
de Visser A. G. M., Elena S. F.
The evolution of sex: empirical insights into the roles of epistasis and drift.
2007 Feb, Nat. Rev. Genet., 8(2):139-149
applications » population genetics & evolution » evolution of sex & recombination
Lippman Z. B., Zamir D.
Heterosis: revisiting the magic.
2007 Feb, Trends Genet., 23(2):60-66
Skipper M.
From genetic interactions to pathway architecture.
2007 Feb, Nat. Rev. Genet., 8:87
Komili S., Roth F. P.
Genetic interaction screens advance in reverse.
2007 Jan, Genes Dev., 21(2):137-142
discovery » techniques » genomic haploinsufficiency modifier screen

discovery » techniques » SGA

discovery » techniques » dSLAM

Onami S., Kitano H.
Genome-wide prediction of genetic interactions in a metazoan.
2006 Nov, Bioessays, 28(11):1087-1090
interpretation & analysisCaenorhabditis elegans
Costanzo M., Giaever G., Nislow C., Andrews B.
Experimental approaches to identify genetic networks.
2006 Oct, Curr. Opin. Biotechnol., 17:472-480
Eddy S. R.
Total information awareness for worm genetics.
2006 Mar, Science, 10:1381-1382
interpretation & analysisCaenorhabditis elegans
Ooi S.L., Pan X., Peyser B.D., Ye P., Meluh P.B., Yuan D.S., Irizarry R.A., Bader J.S., Spencer F.A., Boeke J.D.
Global synthetic-lethality analysis and yeast functional profiling.
2006 Jan, Trends Genet., 22(1):56-63
concepts » synthetic lethalitySaccharomyces cerevisiae
Wang W. Y., Barratt B. J., Clayton D. G., Todd J. A.
Genome-wide association studies: theoretical and practical concerns.
2005 Feb, Nat. Rev. Genet., 6(2):109-118
applications » disease association studies
Kaelin W. G. Jr.
The concept of synthetic lethality in the context of anticancer therapy.
2005 Jan, Nat. Rev. Cancer, 5(9):689-698
concepts » synthetic lethality

applications » disease association studies

Carlborg O., Haley C. S.
Epistasis: too often neglected in complex trait studies?
2004 Aug, Nat. Rev. Genet., 5:618-625
applications » disease association studies
Hartwell L. H.
Yeast and cancer.
2004 Aug, Biosci. Rep., 24(4-5):523-544
interpretation & analysis

applications » disease association studies » cancer

Saccharomyces cerevisiae, Homo sapiens
Moore J. H., Ritchie M. D.
The challenges of whole-genome approaches to common diseases.
2004 Apr, JAMA, 291(13):1642-1643
applications » disease association studies
Fraser A.
Towards full employment: using RNAi to find roles for the redundant.
2004 Jan, Oncogene, 23:8346-8352
discovery » techniques » RNAi

applications » disease association studies » cancer

Caenorhabditis elegans
Hoh J, Ott J
Mathematical multi-locus approaches to localizing complex human trait genes.
2003 Sep, Nat. Rev. Genet., 4(9):701-709
discovery » techniques

applications » disease association studies

Bader G. D., Heilbut A., Andrews B., Tyers M., Hughes T., Boone C.
Functional genomics and proteomics: charting a multidimensional map of the yeast cell.
2003 Jul, Trends Cell Biol., 13(7):344-356
Saccharomyces cerevisiae
Brummelkamp T. R., Bernards R.
New tools for functional mammalian cancer genetics.
2003 Jan, Nat. Rev. Cancer, 3:781-789
discovery » techniques » RNAiMammalia
Veitia R. A.
Exploring the etiology of haploinsufficiency.
2002 Feb, Bioessays, 24(2):175-184
concepts » haploinsufficiency
Badano J. L., Katsanis N.
Beyond Mendel: an evolving view of human genetic disease transmission.
2002 Jan, Nat. Rev. Genet., 3:779-789
applications » disease association studiesHomo sapiens
Cordell H. J.
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans.
2002 Jan, Hum. Mol. Genet., 11(20):2463:2468
applications » disease association studiesHomo sapiens
Cardon L. R., Bell J. I.
Association study designs for complex diseases.
2001 Feb, Nat. Rev. Genet., 2(2):91-99
applications » disease association studies
Forsburg S. L.
The art and design of genetic screens: yeast.
2001 Jan, Nat. Rev. Genet., 2(9):659-668
discovery » techniques

interpretation & analysis

applications » prediction of gene function

Saccharomyces cerevisiae, Schizosaccharomyces pombe
Sham P.
Shifting paradigms in gene-mapping methodology for complex traits.
2001 Jan, Pharmacogenomics, 2(3):195-202
applications » disease association studies
Crow J. F.
The origins, patterns and implications of human spontaneous mutation.
2000 Jan, Nat. Rev. Genet., 1:40-47
applications » population genetics & evolution » mutational load
Barton N. H., Charlesworth B.
Why sex and recombination?
1998 Jan, Science, 281:1986-1990
applications » population genetics & evolution » evolution of sex & recombination
Otto S. P., Michalakis Y.
The evolution of recombination in changing environments.
1998 Jan, Trends Ecol. Evol. (Amst.), 12:145-151
applications » population genetics & evolution » evolution of sex & recombination
Phillips P. C.
The language of gene interaction.
1998 Jan, Genetics, 149:1167-1171
definitions and terminology
Feldman M. W., Otto S. P., Christiansen F. B.
Population genetic perspectives on the evolution of recombination.
1997 Jan, Annu. Rev. Genet., 30:261-295
applications » population genetics & evolution » evolution of sex & recombination
Guarente L.
Synthetic enhancement in gene interaction: a genetic tool come of age.
1993 Jan, Trends Genet., 9(10):362-366
concepts » synthetic lethality

interpretation & analysis

Thomas J. H.
Thinking about genetic redundancy.
1993 Jan, Trends Genet., 9(11):395-399
Avery L., Wasserman S.
Ordering gene function: the interpretation of epistasis in regulatory hierarchies.
1992 Jan, Trends Genet., 8(9):312-316
interpretation & analysis

concepts » epistasis

 


© 2007—2008 Anastasia Baryshnikova (a.baryshnikova@utoronto.ca), graduate student with Charlie Boone and Gary Bader at the University of Toronto.